In a far future Runner 626, people have to run for their lives. The main test to know if you are a survivor is to confront to different adversaries in a background with platforms allowing you to have advantages and disadvantages in your race.
You run for your live. If you lose, you will be dead. So, you have to demonstrate to be the best runner in the world, racing against other human testers and, once you have demonstrated to be the best runner, against the machines created by Robotron, the mad professor who has designed different mechanical creatures to run against them...